The European Infrastructure for Multi-scale Plant Phenomics and Simulation (EMPHASIS) is a distributed Research Infrastructure dedicated to developing and providing access to facilities and services tailored to multi-scale plant phenotyping across various agro-climatic scenarios. The goal of EMPHASIS is to establish an integrated European phenotyping infrastructure, enabling the analysis of genotype performance under diverse environmental conditions. EMPHASIS aims to quantify the diversity of traits contributing to performance across varied environments, encompassing plant architecture, major physiological functions and output, yield components, and quality. By addressing the technological and organizational challenges inherent in European phenotyping, EMPHASIS strives for the full exploitation of genetic and genomic resources available for crop improvement amidst a changing climate. This will be achieved through facilitating transnational collaboration among researchers, institutions, and stakeholders across Europe, while ensuring seamless linkage of data acquisition to a comprehensive data management and analysis system. Promoting FAIR data usage and supply across Europe and fostering the development, evaluation, and dissemination of knowledge and novel technologies are integral aspects of our mission. The primary users of EMPHASIS services encompass a diverse spectrum: scientists and managerial staff operating the installations implement new technologies and standardizations, facilitating effective and cost-efficient implementation of novel methods. Academia and industry users raise varied scientific questions related to basic plant science, applied plant sciences, and other related disciplines. Technology developers find applications beyond the plant phenotyping community, extending to fields such as precision agriculture and medicine. Start-up companies and small to medium-sized enterprises (SMEs) benefit from access to EMPHASIS resources, as in-house development of such resources is typically unaffordable for larger enterprises. Funders and policymakers receive valuable insights through EMPHASIS reports and recommendations, aiding in shaping research strategy agendas to advance Europe's agricultural and plant sciences. Engagement with EMPHASIS contributes to advancing sustainable food security, a concern that resonates with everyone. Together, we strive to foster innovation, collaboration, and progress in plant phenotyping and agricultural sciences for the betterment of society.